Would a wheelset with campy chorus 10 speed hubs and an aerohead oc rim on the rear wheel and aerohead rim on the front wheel be appropriate for a 220lb rider? 32 spokes front and rear.
I have mostly being looking at mavic open pro rims on campy hubs, but I have read those are not the best either. And I understand that campy hubs tend to require more dishing, which is also a bit problematic for a open pro rim.
It probably depends more on the builder than those specific component details.
My first really good bike (French) came with tubulars. I don't recall the hubs, but the rims were Wolber Aspins. The rear wheel was frequently going out of true, until one ride when I finally popped a spoke (I was probably about 220 at that time, maybe a little less). A very good friend who's a first-rate wheel builder (and wrench in general) built me a pair of what was then the new high-pressure "racing" clincher wheels with Campy Record hubs and plain Mavic box rims (aero rims weren't around then), with 36 DT butted spokes. I never had a single problem with them ever, even when my weight ballooned to the 250 range. They weren't very sexy looking, but they were great wheels.
Litespeed Liege, Motorola Team Issue Eddy Mercxk, Surly Crosscheck Cyclocross bike, Fisher Supercaliber Mtn. Bike
I had a set of Centaur hubs built up on aeroheads and they are holding up just fine.. It is more the builder than the rims.. If you want something a little more robust, look at the Fusions or Deep V's if you don't mind a few extra grams..
The DT Swiss RR465 are a nice rim, similar in weight class to open pros but a little stiffer.. Do not even bother with open pros, too many issues with the newer models cracking at the eyelets..
If you want something to train on off the shelf, the Aksiums have held up well for me. Campy wheels like the Khamsin are pretty stout but Campy wheels have a tight bead and it is a pain getting tires on and off of those rims..
aerohead rims are not particularly beefy, they are only around 420 grams or so, doesn't mean catastrophe but there is some potential for trouble if your planning to use these as daily riders. At your weight a velocity fusion would probably be a little bit of a better choice for durability. I am unfamiliar with the dishing issue with campy hubs that you reference but I assume that is why you were looking at using the OC version of the aerohead. Also there are a lot of other places that sell wheelsets where you can easily swap out the shimano freehub body for the campy one. Bicycle wheel warehouse comes to mind for this.
Now days, it is much cheaper to use machine built wheels and generally the weight is less. The G3 Campagnolo line is usually described by its owners as "built-proof". Ribble.com sells Khamsins (1873 g) for $185 and the Zondas (1555 g) sell for $462. I have the Khamnsins and I planning on an upgrade to Zondas. With 2000 miles on them, I haven't turned a nipple on them and they are perfectly true.