My wife is having all sorts of issues for which the standard solution is "Try wearing some bicycling shorts". She has not yet found any that fit her, though; she'd tried some Aerotech shorts based on their sizing chart, which was a disaster - their 4X size "loose fit bike shorts" were far too small and she couldn't get them on at all. (She swears that the site stated 4X was listed as fitting 26, but today the site gives that size as a 20. She'd tried the 3X before after conferring with the sizing chart.)
Ordering clothing in the largest size only to have it be far too tiny to wear had her self esteem shot to hell for days. I have no idea what to suggest at this point.