I'm a 300 pound clyde. Riding a Giant Defy 2. These are the wheels:
rims Mavic CXP22
hubs Formula sealed Cartridge Bearing 24/28h
spokes SAPIM Race, 14/15g
Front tire is a Kenda Kriterium, 700x25 and the rear tire is the same size Gator Skin.
To date, the bike has felt solid. I've never had a bike like this before and it really felt amazingly light, fast, and solid. I've put more miles on it the past two months than I have in the past 3 years. I've noticed a "squishyness" in the wheels the past few rides. I'm not entirely certain that it's not all in my head. Just when I'm riding slowly and turning. It almost feels like the wheels are slightly flexing or the tire is slightly flexing sideways.
I don't know if it's in my head, or just the road, or if I'm starting to get to really know the bike now and very small but typical twitches out of the ordinary are getting my attention. I just had the bike tuned a few weeks ago, I don't think it's loose spokes. There are no other clues, just that slight squishiness that I might be imagining.