I'm around 5'11", 260, and ride a Lemond Zurich. The bike is heavy, but it's steel so it can handle my mass, and the Rolf wheels are about as durable as it gets. Right now I'm running 700x23's and about 108 PSI in the tires to keep minimal contact with the road and decrease rolling resistance (as well as pinch flats, for that matter). Unfortunately, this has taken its' toll on my tires, including gouges and other nasty cracks.
I'll admit, the tires were michelins bought on the cheap, but I maintained them well. However, i'm at a crossroads:
23 or 25 width? Higher/lower psi? Better tires (e.g. Gatorskins)? How do you clydesdales out there keep your tires in one piece while still being able to keep speed up and rolling resistance down?