Really, compared to the price of gas and auto maintenance, bike tire/tube cost is no object.
I have a five-mile commute through the lower income neighborhood of the big city school where I teach. Bike also gets used to shop/run errands when I can. Route includes much hopping up and down curbs, old uneven sections of pavement, short cuts through unpaved alleys, and sections where I have to ride on and off of the pavement alongside the highway.
Continental Town and Countries have answered well for this in the past. Looking for a general equivalent in terms of low rolling resistance/some off road tread, but one with kevlar protection.