Let's do a Century
Join Date: Oct 2004
Location: North Carolina
Bikes: Pinarello Prince/Campy SR; Cervelo R3/Sram Red; Trek 5900/Duraace, Cervelo P2C/Duraace
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I would guess that one of the elements that factors in is the type of roads you ride. If you're riding rougher paved roads that have a lot more debris and loose gravel the extra flat protection might be worth considering.
I've never really had an issue with flats from road debris myself but know some here do.
Personally I'd prefer to ride the 25's (or I ride 23's) and keep an adequate amount of air in them to avoid snakebite punctures. I'm not a weight weenie but I do notice when a tire is heavier than another, especially on the hills or if I'm trying to accelarate to catch someone ahead of me.
If it were me, I'd go with the smaller tires and make sure I had an extra tube or two with me.