I've been tinkering with my Trek 7600 hybrid that I picked up used last November. Initially it felt okay, but was somewhat uncomfortable.
Since then I've done the following:
Changed out the saddle, which was a rather generic hybrid saddle, to a Terry Cite Y Gel, which struck me as having some potential of being comfortable on an upright bike.
Tightened the suspension seat post and suspension fork to their maximum positions.
Adjusted the seat height a couple of times.
Swapped out the 1" riser handlebar for a 3" riser, that also has a bit more sweep.
First adjusted the adjustable stem to 60 degrees with the 1" riser bar, then down to 40 degrees with the 3" bar.
Installed bar ends (picked up used with a few scrapes for $4).
Made non-OCP move and put a yellow bottle cage on a red bike. The yellow cage had been on sale for $2.
I took it out this morning for a spin around the neighborhood and it felt pretty darn good. But the "boys" were a bit cramped. Brought it back in and adjusted the saddle angle by one more notch forward and took it out again for a couple of mles.
Wow!. It was wonderful. Less weight on my hands than last year. Comfortable shoulders. Saddle felt good (of course this could change dramatically at mile #10). It just fit. Riding was suddenly much more natural and comfortable. I have never felt so comfortable on a bike in my life.
It was fascinating to me as to how much difference that last little click on the saddle position made.
Now it will be back to the Sun recumbent and my old trusty Bridgestone CB-1 to continue tweaking them.