I think we had a discussion some time ago about the possible threat that eastern coyotes (Canis latrans) may pose to humans.
Now, coyotes are small predators and generally go after small rodents, rabbits and other small game. Two coyotes (a pair) may cooperate in hunting but humans would be far too large for them to handle. I thought that it was highly unlikely that coyotes posed any threat what so ever and said so.
A little while ago, I came across an interesting article. Many eastern coyotes are very large for coyotes. There is convincing genetic evidence that the coyote has mated with Canis lupis (the timber wolf). Since, much of the eastern US has had a white tailed deer population explosion, being able to take on larger prey would be a huge advantage for coyotes. Also, being larger and with more powerful jaws than normal coyotes, these hybrids may actually pose a risk to humans especially small humans.
Of course, there is an advantage in that the hybrids may curb the pesky white tail populations. The downside is that coyotes are extremely resilient and are nearly impossible to eradicate. The upside is that I do not think that they pose much of a threat as long as people take reasonable precautions. Of course, since when have people taken "reasonable precautions"?