I'm still fighting saddle comfort issues. I've been through half a dozen saddles, on a Defy Endurance bike on which I have been fitted. It turns out my sit bones are far apart, and I need a wide saddle - the common 140mm and 150mm wide saddles leave the bones hanging over, and are horribly uncomfortable. I resorted to trying a Bontrager Commuter Gel CRZ+, and it resolved the sit bone pain I was suffering, and despite the fact that it has a channel for soft tissue relief, the sides of that channel are still putting some pressure on the soft tissue, despite wearing padded shorts. I've lowered the saddle nose by 2°, and that has helped, but there is still pressure where, as I understand it, there shouldn't be any. I'm getting frustrated.
I'm beginning to wonder if I need to tinker with the fit - something I have been reluctant to do. The seat is already all the way forward on a zero offset post, and it is KOPS correct - I can't imagine I need to be more forward. The handlebar is all the way up. The saddle height, arm angle, leg angle, etc. are all correct as per the fitting. I've considered tinkering with all those parameters, though. Maybe lowering the seat, raising the sweep on the handlebar to raise the hoods, etc.
If anyone has any constructive suggestions or comments on things I might try, I would welcome them.