I have dual 22" widescreen monitors at work. Two widescreen monitors side by side is pretty wide, which infringes a little bit on my space to lay out large drawings. I need to do a little rearranging and see if I can't improve this. It is helpful to me to have lots of space. Usually I sit where one of the monitors is more directly in front of me and I put my main apps there when I'm working on them. Secondary apps, windows I'm not working with right away, I drag to the other monitor. This is much faster for me than using the taksbar to switch apps because believe it or not when I shift focus to the taskbar to find another window, it interrupts my thought process. I do a lot better if I can move my cursor over to another window and drag it back in front of me, this is much less of an interruption.
At home I have an older 20" LCD (4:3) that I bought on ebay so I would get something better than a TN panel. At times I wish it was larger, when I need to have several windows open to work with.