Sometimes, either by choice or circumstance, you have to do a reboot in your life and start over. Moving to a new place, ending a relationship, changing jobs, etc. The process might be painful but I've always found that things turned out better in the long run for me.
I moved to a smaller house several years ago and now I totally love it. I had to remodel pretty much the entire inside and almost the entire yard, but now I wouldn't want to live anywhere else.
I changed jobs very unexpectedly a couple of years ago. I was getting frustrated with my current job and answered a headhunter's email on a whim. I didn't intend to take the job but they made me a great offer so I left and now I really like the new job.
Have you ever started over and realized later that it was a really great thing to do?