One of my favorites is a run from 29 Palms to Las Vegas. 129 Miles of uninterrupted driving.
It's way out in the desert, so much of the traffic ignores any posted speed limits. From 29 Palms to Amboy is pretty much straight line driving with few turns. In Wonder Valley you pass a lot of small houses.
At Amboy you can enjoy the sights on Route 66. There is a volcanic crater and a gas station. Next, you enter the Mojave National Preserve.
Turning onto Kelbaker Rd. You can enjoy long traffic-free stretches, punctuated with sharp corners.
At Kelso there is an oddly elaborate train station.
On up Kelso Cima Road you have to watch out for the cows. There is nothing keeping them from walking onto the roadway, and they do. You have to keep a wary eye open for them as you speed along.
Once you get to Nipton Rd. It's time to start winding down and get ready for freeway traffic on the I-15 heading towards Las Vegas. Ahead is a dry lake and on the other side, the New York mountains in Nevada.