I'm building a commuter frame for my 5'4" wife. I intended on basing it on the frame I just built for myself, which was built around 650b wheels. I got what turned out to be a great deal on the set of wheels ($100 shipped for new wheels with Deore hubs and ZAC 19 rims), so it all came together pretty well.
Well, now I'm looking for a similar deal on 650b wheels for my wife, and the least inexpensive wheels I'm finding are $240 from Riv. Knowing that she'll benefit from the reduced design compromises that 650b wheels would have for a frame her size over a 700c wheeled frame that would accept 35mm tires and fenders, I got to thinking that I should just save myself the wheel search hassle by just building her frame around 26"/559 wheels. Rims are definitely not a problem, nor are tires....but I like how 650b wheels with Fatty Rumpkins roll. Wifey would benefit from more standover.
So my question is this...should I modify my design to accomodate the different (and more available) 26" wheels? Or should I stick with my original plan? Have any of you ever made design changes based upon factors like this?