Preventing Saddle Sores
Saddle sores are painful, but they don't have to be a part of your biking life. While it's true that many new or infrequent riders will experience them, even the more experienced rider can have saddle sores, particularly if you neglect your hygiene or equipment.
The first rule of thumb is to find a high quality saddle that fits you. My wife found out the hard way as she rode on a man's saddle once, that it's not a pleasant experience. Your saddle should keep your body stable, and yet absorb your weight. Be aware of overly soft or wide saddles, they can cause chafing.
Once you've found a good saddle, you need to make sure it's placed properly on your bike. It shouldn't be too high or too low or angled incorrectly. All of these things can cause saddle sores.
What you wear will also influence saddle sores. Your shorts should be dry and clean. I also advise that you don't wear underwear while riding, as it can rub you the wrong way. The shorts with the natural chamois liner will help with air circulation.
You should always wash your shorts after every ride. You can even dry your shorts in the sun, because the ultraviolet radiation will help kill bacteria. This is but another good reason to have more than one pair of shorts.
As for riding technique, try riding out of the saddle over any rough spots, like railroad tracks, etc. And stand up to ride a few minutes out of every hour you spend riding to allow for better air circulation.
If you get a saddle sore, the best thing for it is good hygiene. Wash it with an antibacterial soap, and wear clean underwear. Also make sure you keep you crotch dry and free of salves, failing to do this can actually cause the bacteria to stay alive.