I suspect that ASICs seamless underwear will work just fine. I wear a pair of Exfficio underwear that I purchased from REI and, with a clean butt (a quick wash before a ride) I don't have any problems at all - even on century rides. I quit using chamois cream a good while back. I usually hand wash the underwear after each long ride, or perhaps several shorter rides. No smell, no skid marks and, they last and last.