You need a beefy u-lock around the rear wheel, just behind the seat tube, attached to a steel post that is set in concrete. Don't put a u-lock around any part of the frame, because crooks will attempt to use the frame as a lever to break the u-lock...turning the frame into a pretzel.
Use a cable lock (such as the beefier combo lock models) to attach the front wheel to a locking post or to the frame, or use a mini u-lock to secure the front wheel to the frame.
But, an experienced and skilled "pro" with power equipment can defeat any lock in ten minutes or less. Don't leave a bike out of your sight for more than ten minutes if it is worth more than a few hundred bucks, or is a bike you will miss.
A woman in my neighborhood locked a $4,000 bike to a rack outside the neighborhood library and was shocked to find out that evening that someone had used power tools to cut her $100 lock...well, of course...a $4,000 bike left unattended for nine hours is gonna disappear.