I used to live near Orlando (Winter Park, just on the east side), and I've been down there multiple times for business trips and vacations with the family.
If you're staying in the theme park stretch along I-4 southwest of the city, if you don't have a bike rack on your car or some other way to ferry your bike so you can drive someplace else to bike, enjoy your week without biking. The stretch between the area around Sea World and down to Disney is a zoo full of drivers not familiar with the area.
But if you're driving and have a rack on your car, bring the bike.
Just beware. It will be hot and humid by May.