I got a new Brompton last week and fitted it with a new Brooks B-17 saddle, and am feeling a bit of pain. The saddle is new, and hard, and needs breaking in. My other bike also sports a B-17 which has a few thousand kilometers on it, and is very comfortable.
The main cure for saddle pain is 1 part adjustment, and 3 parts time. You need to make sure your body is broken in before making many saddle adjustments, even a perfectly adjusted saddle will cause pain if you haven't been doing much riding.