Join Date: Jan 2006
Location: Melbourne, AU
Bikes: Cannondale T800, Northwood tandem, 1970s Gitane fixxed 45x16
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Think weight, bulk, also what proportion of the time you'll be loading it up.
If you regularly commute, shop, do recreational rides, and plan to go camping with it - get a tourer. It will be stiffer and steadier with a load, and the back end will be long enough that the panniers there won't annoy you.
If you commute, do group rides on a Saturday, like to ride fast or far, and will only be carrying rain gear and a change of clothes (or very light / compact camping gear) - go a lighter bike.
Also watch for toe overlap if you're mostly using it for commuting. It is a real pain in traffic, or start-stop riding where there are hills. It is less of a concern if you're doing long miles on an open road.