World's slowest cyclist.
Join Date: Oct 2007
Location: Londonderry, NH
Bikes: Cannondale CAAD5 and Cannondale Rush
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My wife has a 4500WSD. It's worked well but hasn't seen a lot of riding (because she never got in to biking, so the thing sadly sits in the garage). I had a similar Trek that I put a ton of miles on before giving to a friend. Never had a problem with it beyond routine wear and tear.
The biggest thing to concentrate on when buying a bike will be fit. Get something you're comfortable on, and don't limit your choices to one brand or just women's specific. (BTW, most manufacturers make women's specific bikes, not just Trek).
Also, don't forget to budget for periferals: saddle pack, tire irons, pump, helmet, gloves, padded shorts, etc... You could easily spend $100 on basics.