If you have Time cleats then yes.
Santa Cruz Tall Boy
Cannondale CAAD 8
OP- it's the cleats, not the shoe.
As with mud, life, too, slides by.
i was just worried the cleat of the shoes (knobby crap) would get in the way.
I had to cut a little of the knobs off of my older Specialized mountain shoes so that I could clip in better on my Time Atacs.
Newer shoes might be a little different.