That's a question that's almost impossible to answer for you. Saddle fit is such a varied and subjective thing. What works for me might not work at all for you. At the shop, or advising friends, I try to steer them towards the least amount of padding they feel comfortable with, and take into account what type of riding they'll be doing. Too much padding in a saddle seems to sort of bunch up and it can put pressure on areas you wouldn't think it would on a long ride. Big plush saddles are ok for short jaunts but my personal experience is that over longer periods of time that comfort disappears.
I guess my butt is battle hardened. Like I mentioned earlier, I like a little padding on my MTB saddles, but for my road rides a Brooks right out of the box is comfy.
I bought a beer cruiser from a friend not long ago. It's one of my main rides for commuting and grocery getting. It had a thickly padded Selle San Marco and I had to ditch it in a couple of days for a brooks. I never looked back.
I get a lot of saddle time on different seats test riding new bike builds and customer repairs. I have personally found some of the new specialized body geometry stuff to be fairly comfortable. Usually I sport WTB saddles on my Mtn. bikes. You may hate them though. Go hit the LBS and put in a few test rides to see what you like. It's often not possible to put a saddle on your bike to try out, but you can take a new bike with a different saddle out for a spin at a lot of shops with some sort of deposit, often just an I.D. for them to hold. Just be considerate and careful not to wear out your welcome.
Look for a saddle that provides a good platform for your "sit bones". Even distribution of weight between the two hard points that you sit on. Also, keep in mind that a quick jaunt around the block might not tell you right away what will work for you on a two hour ride.
Good luck, I know guys that have spent 20 years in search of the perfect throne, with not a lot of success yet.
Last edited by BFW; 08-06-09 at 09:12 PM.