I demoed a Safire and hated it. The geometry was just really freaking awkward, despite the fact that I ride a women's specific Specialized road bike. I ended up with a unisex bike and don't regret it one bit. But that's just me, and YMMV.
2009 Cannondale F4 with Lefty Speed DLR, 2010 Trek 1.1
The best thing for you to do is get on both bikes and see what you like the best. It is also my opinion that the lefty on the Cannondale is an amazing Fork/shock and well worth it. I have a lefty on my F4 and don't want any other kind of fork.