I always set my seat height 1st, that is the most important thing.
I set my seat level using a small level at the middle of the saddle and set the fore-aft position so the ball of my foot is just behind the pedal axle for more pedaling torque.
My saddle is about 4 inches higher than my handlebars which gives me a better aerodynamic position and more control (I am pretty flexible and have a strong core).
You should never use the handlebars to support your upper body, this will make your hands go numb quickly.
I also place my hands on the bars so the outer heel portion of my palm is on the bar, never in the middle of the palm which can affect your ulnar nerve.
Keep your feet heavy on the pedals and keep your hands light on the bar.
It can sometimes get frustrating getting your bike dialed in for your riding style.