Those roads are safe "enough" but they sure aren't the best choice. If those end-points are important, I would cut off at Buena Vista and go over Cottonwood. The west side is dirt, but ok on fatter road tires (check for current conditions, it's been a couple years since I rode it). 285 and 50 are busy, and there tends to be south wind in that valley, so you'll have a lot of headwind.
If you are looking for ride ideas and those end points aren't important, let us know what your parameters are, I probably have some ideas.