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  1. #1
    Senior Member serpico7's Avatar
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    Soap to defeat EPO test

    Athletes Fool Test of Banned Drug by Using Soap, Scientist Says
    2007-10-29 00:24 (New York)


    By Alex Duff
    Oct. 29 (Bloomberg) -- A few grains of household soap
    powder can destroy the banned drug EPO in an athlete's urine
    sample, wrecking a test that cost $2 million to develop, said
    Mario Thevis, an anti-doping researcher in Cologne, Germany.
    Scientists made the discovery after a former Tour de France
    cyclist said he was given an unidentified powder to sabotage
    surprise tests, said Thevis, who works at the World Anti-Doping
    Agency-accredited biochemistry unit of German Sports University.
    ``One or two tiny little granules of washing powder are all
    that is needed,'' Thevis said in a telephone interview last week
    from Cologne.
    Synthetic EPO, or erythropoietin, was developed to treat
    anemia by increasing red blood-cell production. Athletes take it
    illicitly to improve endurance. Authorities began checking
    competitors for it at the 2000 Olympics in Sydney.
    ``Cheats appear to have found a way around the test with
    backyard science,'' said Robin Parisotto, a researcher in
    Canberra, Australia, who helped develop the test for the drug.
    The International Olympic Committee and the Australian
    government spent $2 million to develop the test, he said in a
    telephone interview Oct. 26 from his home.
    Thevis, one of the researchers in the study, said anti-
    doping authorities may need to start checking for protease, a
    class of enzymes that destroys EPO and is in soap powder,
    dishwashing solution and contact-lens cleaner.

    Enzymes

    The body uses naturally occurring enzymes to break down
    proteins, such as EPO.
    The drug is sold as Aranesp by Amgen Inc. and Procrit by
    Johnson & Johnson. They were among the world's top-20 selling
    drugs last year, generating $7.3 billion between them.
    There's no reference to protease on the World Anti-Doping
    Agency's list of banned substances. Olivier Rabin, the agency's
    science director, was unavailable to comment, spokesman Frederic
    Donze said. IOC medical director Patrick Schamasch didn't
    immediately respond to a phone message and e-mail seeking
    comment.
    In May, Bjarne Riis, the 1996 Tour de France winner, said
    he took EPO for five years during his career. Cross-country
    skiers Johann Muehlegg and Larissa Lazutina gave back their
    Olympic gold medals at the 2002 Winter Games after testing
    positive for EPO.
    Jesus Manzano, a former Tour cyclist who left the sport in
    2003, said athletes still use EPO while training because it
    leaves the body quickly.

    Manzano

    Manzano said in 2004 that he used EPO when he was competing.
    He was given a red powder to use if anti-doping officials came
    to his home for a surprise test. He said in an interview in
    April at his home in Madrid that he didn't know what the powder
    was.
    His former team, the now-defunct Liberty Seguros, has
    denied wrongdoing and said Manzano acted independently.
    Thevis said using soap powder would destroy all EPO in
    urine, both synthetic and what is produced naturally by kidney
    cells.
    No EPO was found in 17 percent of 3,050 athletes' urine
    samples examined between 2003 and 2006 by the Swiss anti-doping
    laboratory in Lausanne, said Neil Robinson, who helped compile
    the study published in this month's edition of medical journal
    Clinica Chimica Acta.
    ``You have to be very careful when accusing anyone,''
    Robinson said in a telephone interview last week from his lab in
    Lausanne. ``You can have little EPO by drinking huge amounts of
    water. It will also deteriorate if you're transporting a sample
    a long distance, say, from Uganda.''
    It also could be difficult to prove that laundry soap
    hasn't come from an athlete's clothes, Michael Ashenden, an
    Australian anti-doping researcher, said in an interview.
    Robinson said the simplest solution to stop tampering is to
    urge vigilance by sports officials who collect urine samples.
    ``Pay attention,'' he said. ``And make sure athletes wash
    their hands first.''

  2. #2
    Senior Member johno's Avatar
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    That's been around for a while. What first tipped the authorities off is that some riders were showing no epo at all, not even natural.

    Ullrich was rumored to be one of those with epo free piss in 2005.

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