2013 Kona Jake, 2008 Kona Major Jake, 2013 Kona Jake the Snake, 2006 Kona Kula, 2012 Ridley Excalibur, 2008 Surly Long Haul Trucker, 2001 LeMond Buenos Aires
1) I use the same setup for both, but my road setup isn't very aggressive. You generally need to favor bike control over aerodynamics, so something more like the MTB setup may be good.
2) It depends on the wheels and how attached you are to them. If it wouldn't break your heart to have to rebuild the wheel, then use whatever is lightest. A solidly built wheelset will usually make it through a CX race without so much as needing to be trued, but things happen. I've been told you shouldn't race with any equipment you couldn't replace if you had to.
1)I've been told you shouldn't race with any equipment you couldn't replace if you had to.
This is a true statement, for sure.
As for the wheels, are you heavy? If you're too heavy for your wheels, then no, you shouldn't ride them. Not because you might break them, but because it'll screw up your race having broken spokes or untrue wheels.
All other factors being equal, I don't worry about riding bladed spokes. My race tubular wheelset has bladed spokes with a 20/24 front/rear setup. I'm 150 pounds and I haven't broken a spoke yet. I also have 32hole wheels with butted spokes that are absolutely bomb proof at my weight.