Odd but wonderful
Since you asked, but were not specific.
Upon returning to cycling heavier and in decidedly worse shape, I couldn't find a seat that didn't cause numbness. I was about to give up cycling again before finding my spongywonder hornless seat. After getting in better shape used it on a 540 mile tour.
I'm hesitant to broadly recommending them, as they are not for everyone. They take getting used to, and proper adjustment is paramount. With all my weight on my hip bones, you get some local discomfort there. When sitting back down after standing up, it is harder to center yourself until you get used to it.
A local rider purchased an inexpensive copy on ebay, and it was unridable.
There is another company making something similar but spring loaded called a spiderflex. I've never seen or ridden one in person, so can't recommend it, but it looks interesting.
After 4-5 years the spongywonder is now on the bike I'm training on the most, usually my hybrid bike. I also have a seat with a big cutout that is tolerable to swap out.
When my relative injured his prostate riding a dirtbike, he bought one too. =]