I'm about 20 minutes away from posting a beautiful cannondale on craigslist and hanging it up for good.
Saddle sore, angry pimple, boil whatever, left side only, crease between butt and leg. Perfect hygine, 20 different saddles, 143/145/155/168 sizes. Assos/garneua/PI/Performance/Voler/Castelli bibs. Cant ride 20 miles without one. I can feel the pressure on that side of my leg whenever I ride, it rubs the saddle while my right side is free and clear. Cannot get it to stop. Every chamois cream on the market. Tea tree oil/rubbing alcohol to treat it. They will go away but then after a ride it will come back.
bought a shim, would not stay put with my SPD cleats. Bikefit brand. Tried on both shoes.
The ONLY thing that will prevent it is to lower my saddle until its even with my current bar height, which puts me at a very upright position and does not let me pedal efficiently causing knee and hammy pain as well.
Have rode for 4500 miles in nothing but frustration and pain and I'm also broke as hell, spent every dime on a fix.
Had a serrota fit done, got a saddle sore from the fit process.