Obviously, the more miles they ride, the more they will be able to learn about their setup. Eventually, if you ride long enough you begin to get personal likes and dislikes, and that's more along the lines of what you see in setups for Lance (as you metioned) or Jens Voight. But, with all due respect to them, we see a lot of category racers trying to emulate what they see in magazines and it does not work for them.
And as someone mentioned, cleats and pedals are huge. Knee, foot, hip pain, numb toes, none of that should be happening.