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  1. #51
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    Quote Originally Posted by Velo Vol View Post
    I thought aspirin is supposed to reduce the risk of heart attacks?
    Yes, but it is the only NSAID that does.

  2. #52
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    Quote Originally Posted by Velo Vol View Post
    I thought aspirin is supposed to reduce the risk of heart attacks?
    It does.Aspirin 81mg day decreases "most peoples" risk of having a heart attack.
    What one poster was wondering- if you use a NSAID might IT decrease the effectiveness of the aspirin in lowering my MI risk.
    So the concern is if I take this ibuprofen will I negate the cardiac protection I get from the 81mg of aspirin I'm taking.
    The answer is unclear for now.
    (aspirin is LITERALLY a NSAID but it usually isn't lumped in the term Non Steroidal Anti Inflammatory Drugs)

    What is clear is NAPROXEN has the best cardiac profile of the NSAID
    But it seems to have the "least safe" highest gastrointestinal complications profile- which is EXACTLY what you would expect if it is closest to aspirin in what it does to platelets(decreasing adhesion) and perhaps aspirin like "rough on stomach"

    -Opiate prescribing- or proscribing in surgeonstones case-is a long running argument and cycle in USA medicine.
    During Restrictive phases patients in pain suffer more -
    Liberal prescribing phases produce more prescription drug addicts -profit motive always kicks in
    Last edited by phoebeisis; 12-30-13 at 05:47 AM.

  3. #53
    Senior Member hillcrawler's Avatar
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    Do you think the articular cartilage damage is a kind of arthritis? Or is it something that leads to an arthritis? My MRI result was mentioning a "Grade II Cartilage Degeneration". And i found this on wikipedia:

    The International Cartilage Repair Society has set up an arthroscopic grading system by which cartilage defects can be ranked:

    • grade 0: (normal) healthy cartilage
    • grade 1: the cartilage has a soft spot or blisters
    • grade 2: minor tears visible in the cartilage
    • grade 3: lesions have deep crevices (more than 50% of cartilage layer)
    • grade 4: the cartilage tear exposes the underlying (subchronal) bone
    riding with pretty ****ed up knees since 2012
    http://www.strava.com/athletes/924895

  4. #54
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    Quote Originally Posted by rpenmanparker View Post
    No ride in this weather. I have a strong aversion to chilly weather. Say, I didn't sell you a pair of light Al wheels a while back, did I? Yeah, I was that at the first game ever. Can you say, "Billy Kilmer?"
    Quite a difference.
    Light wheels-hmmm- was it in person? were they 26 MTB or 700c?
    I did buy some MTB wheels-fair while back-
    and I traded for a 700c-a while back?
    I don't remember the wheels being "light" or expensive-the MTB were $50 maybe-so couldn't have been too light.
    In the past I bought sold a fair amount,so..

    Heck Billy Kilmer wasn't one of of worst QBs-pretty sure after he left the Saints he brought the Redskins to the Superbowl-no idea how with those fluttering spirals,but...
    Well Saints won- we are killers at home.Now Philly-plays outdoors-and unfortunately that would be in Philly.....in Jan...so...

  5. #55
    Senior Member Notgrownup's Avatar
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    I take Enbrel, Mobic and Methotrexate but when i cycle my knees feel really good after a trek...I start relatively slow and increase my speed as i go...From the advice of many here i have increased my cadence and it really helps....I am gonna look into this Anatabloc...looks interesting.
    BE THE PERSON YOUR DOG THINKS YOU ARE.....

  6. #56
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    Quote Originally Posted by Notgrownup View Post
    I take Enbrel, Mobic and Methotrexate but when i cycle my knees feel really good after a trek...I start relatively slow and increase my speed as i go...From the advice of many here i have increased my cadence and it really helps....I am gonna look into this Anatabloc...looks interesting.
    Funny! Back in the early '70s I did my Ph.D. thesis on an improved synthesis of methotrexate. The goal that was accomplished was a purer, less toxic form of the drug with fewer side effects due to impurities. I don't think my synthesis ever achieved any commercial application. Nevertheless the stuff is everywhere now. Back then it was only (or mostly) used for cancer chemotherapy. Then I started hearing about it being used to treat psoriasis. Then psoriatic arthritis and rheumatoid arthritis. I saw online the other day it has some efficacy in cases of juvenile asthma. I imagine all these applications are now just the tip of the iceberg. Powerful poop.

  7. #57
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    The Antabloc-$100 for 20 days.Not horrendously expensive-IF it works.
    However I went to a Antabloc site-found this-hope it comes out.
    The CLAIMS- are a BIG RED FLAG- they are out and out lies-SCHIZOPHRENIA EPILEPSY AUTISM (preying on parents)???
    The "trick" on all these conditions is folks with these problems have good periods and bad periods-part of the natural history of those diseases. So folks spend the money-20% maybe 40% will notice some improvement. Yes there WILL be improvement-
    But it will have NOTHING to do with their usually worthless-occasionally toxic-supplement.
    Chronic pain is the PERFECT condition for these scammers.It comes and goes-
    and Chronic unrelenting pain is sooooo debilitating- patients will try ANYTHING.It grinds patients into DUST!
    Maybe this stuff is harmless-other than the $100-Pretty close to zero chance these folks have discovered some "new" safe anti-inflammatory with "no" side effects.
    I really hate these SUPPLEMENT folks that make those sorts of claims-cruel greedy scammers(their MDs-know those claims are BS).Not sure which claim is the worst-maybe Autism because they are taking advantage of parents who want the best for their child-
    Just keep your eyes open-who knows I could be wrong-might actually "cure" Autism.(ZERO chance)-
    BELOW IS THEIR SITE INFO-
    Reilly took part in a clinical trial of Anatabloc under the care of Dr. Dale Wilson. He is in charge of the local portion of a national study on Anatabloc.

    "At this stage in my career, to be doing something like this is really a thrilling for me," said Dr. Wilson.

    The creators of Anatabloc promote the supplement for anti-inflammatory support of the immune system. This is potentially helpful for a variety of conditions.

    "Alzheimer's disease, Parkinson's disease, autism, epilepsy, schizophrenia - things that we never before had any idea what the etiology of the disease could be. Heart disease, diabetes, arthritis, inflammatory disease of the bowels like Crohn's disease, [the list goes] on and on. And one of the most intriguing deceases is fibromyalgia," said Dr. Wilso

  8. #58
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    Quote Originally Posted by rpenmanparker View Post
    Funny! Back in the early '70s I did my Ph.D. thesis on an improved synthesis of methotrexate. The goal that was accomplished was a purer, less toxic form of the drug with fewer side effects due to impurities. I don't think my synthesis ever achieved any commercial application. Nevertheless the stuff is everywhere now. Back then it was only (or mostly) used for cancer chemotherapy. Then I started hearing about it being used to treat psoriasis. Then psoriatic arthritis and rheumatoid arthritis. I saw online the other day it has some efficacy in cases of juvenile asthma. I imagine all these applications are now just the tip of the iceberg. Powerful poop.
    Methotrexate was considered-waaaay back in March 2007 for my wife's vasculitis-Methotrexate Azathoprine and Cellcept. At the time Cellcept was the "new drug" for vasculitis-there were some positive studies-made it look the "best".She is still on Cellcept-but it seems to have become much less effective.Recent study -2011-Clearly showed it was less effective than Azathoprine-time to relapse/disease flare was better on Azathoprine(Immuran-).
    Methotrexate is not uncommonly used for vasculitis and many other autoimmune disorders-reasonably safe reasonably effective.
    Yeah a real oldie but goody.
    Last edited by phoebeisis; 12-30-13 at 10:56 AM.

  9. #59
    Senior Member George's Avatar
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    I'm on Methotrexate and Imuran and I have to say I feel pretty good most of the time.

    I think I'm going to have to get wrist surgery next month for some lumps in my wrist. I'll find out Jan. 14. I wish they could stick a needle in there to draw out, whatever they have get out, but I guess that's to easy. Or I should sat hopeful.
    George

  10. #60
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    Quote Originally Posted by George View Post
    I'm on Methotrexate and Imuran and I have to say I feel pretty good most of the time.

    I think I'm going to have to get wrist surgery next month for some lumps in my wrist. I'll find out Jan. 14. I wish they could stick a needle in there to draw out, whatever they have get out, but I guess that's to easy. Or I should sat hopeful.
    I see you're near Houston. If you have any question about your doctor and would like another opinion, go see Dr. Mark Henry at the Hand and Wrist Center in Park Plaza medical office building on Binz at Caroline in the Houston Medical Center. The guy is a genius. Look up his bio online. He is very, very impressive. Straightened out a very nasty case of tennis elbow for me.

    Ya know, years ago in the '80s and early 90's before I-10 really developed, we used to cycle on the service road on Sundays from Kirkwood to Brookshire and beyond. It was really nice riding back then. Good road and safe. Not so much now.

  11. #61
    Dog is my co-pilot 2manybikes's Avatar
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    Quote Originally Posted by surgeonstone View Post
    Oh, and never, ever, EVER take narcotics for arthritic pain. Not even the pseudo narcotics like ultram. Down that path lays misery and heartache and disaster. NSAIDS only, then surgery if necessary.
    Generally speaking to everyone reading this, that's a good recommendation. But, some of us can take tramadol or ultram when needed, and stop when needed without anything more than just being a little tired for a couple of days.

    Not directly related to the above, my rheumatologist says treat RA aggressively when bad to prevent irreversible damage, and to back off when possible.
    [SIGPIC][/SIGPIC]

  12. #62
    Senior Member George's Avatar
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    Thanks I'll have to check him out.

    My rheumatologist gave me a doctor called David Hildreth. He's been around for a while, so I'll see what he has to say.

    I actually ride out of Cinco Ranch and go out towards Fulshear . I go to Zube Park on the weekends and Chappell Hill as well, when I want a good workout. I'm retired so it's not to bad riding during the week around here.
    George

  13. #63
    VFL For Life Velo Vol's Avatar
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    Quote Originally Posted by phoebeisis View Post
    Methotrexate was considered-waaaay back in March 2007
    It was discovered in 1947, for leukemia, not arthritis.

  14. #64
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    Right-methotrexate-cytoxan old drugs-potent shotguns-
    they originally were "anti-cancer" drugs-but they were repurposed years ago as Rheumatology drugs-suppressing the immune system.
    My wife has vasculitis-all four drugs mentioned-methtrexate azathoprine(imuran) cytoxan cellcept-are used for autoimmune vasculitis
    but they started "life" with other indications.
    Cellcept and Azathoprine were originally anti rejection drugs-for transplant patients.

    Rituximab-monoclonal antibody(anything ending in mab is a Monoclonal antibody)-$7000 per treatment-IV- was originally designed for B-cell lymphomas/leukemias-
    It has been repurposed for many autoimmune disorders-as have other MABs
    Safe bet some of the folks here will be treated with MABs of one sort or the other
    They are more specific than the older drugs-should have fewer side effects-not none, but fewer.

  15. #65
    Senior Member hillcrawler's Avatar
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    I discovered another golden rule today; Stretching.

    “Riding a bike is not something that we evolved to do,” says Mark Simpson, lead strength and conditioning coach at the English Institute of Sport, who works with the British Cycling team. “It’s not a natural movement like running or walking, and is therefore more likely to cause muscular imbalances and postural changes.”

    “If muscles get tight, they pull on bones and put things out of alignment, increasing the risk of pain, discomfort and injury,” Bogue says.
    I think this is very important piece of information.
    riding with pretty ****ed up knees since 2012
    http://www.strava.com/athletes/924895

  16. #66
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    Quote Originally Posted by George View Post
    Thanks I'll have to check him out.

    My rheumatologist gave me a doctor called David Hildreth. He's been around for a while, so I'll see what he has to say.

    I actually ride out of Cinco Ranch and go out towards Fulshear . I go to Zube Park on the weekends and Chappell Hill as well, when I want a good workout. I'm retired so it's not to bad riding during the week around here.
    By all means follow your rheumatologist's recommendation. Just letting you know Dr. Henry is a very valuable resource.

    Yes, years ago Fulshear was the usual furthest point out for the rides that started on the Katy Freeway service road, but back then we were starting much further east, so that was a significant ride. It's too bad that development has shut down those routes to sensible cyclists, but c'est la vie.

  17. #67
    Ghost Ryding 24/7 Ghost Ryder's Avatar
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    @: OP

    Also try using a foam roller too.
    It feels nice to roll out sore muscles.
    I've been considering Yoga, but like the idea of Pilates better.
    Giant Defy Dura Ace : Rip/Hammer-Specialized Allez Ultegra/105 : Recovery/Spinner-Specialized Allez Red : Trainer-Kona Major(Rad) Jake : Down & Dirty

  18. #68
    Senior Member hillcrawler's Avatar
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    Quote Originally Posted by Ghost Ryder View Post
    @: OP

    Also try using a foam roller too.
    It feels nice to roll out sore muscles.
    I've been considering Yoga, but like the idea of Pilates better.
    I don't think spiritual awakening would have any impact on my knees but i will get a foam roller soon.
    riding with pretty ****ed up knees since 2012
    http://www.strava.com/athletes/924895

  19. #69
    Long Distance Cyclist Machka's Avatar
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    Quote Originally Posted by hillcrawler View Post
    I don't think spiritual awakening would have any impact on my knees but i will get a foam roller soon.
    Spiritual awakening?

  20. #70
    Senior Member hillcrawler's Avatar
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    Quote Originally Posted by Machka View Post
    Spiritual awakening?
    When you say Yoga that is the first thing comes to my mind.
    riding with pretty ****ed up knees since 2012
    http://www.strava.com/athletes/924895

  21. #71
    Ghost Ryding 24/7 Ghost Ryder's Avatar
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    Quote Originally Posted by hillcrawler View Post
    I don't think spiritual awakening would have any impact on my knees but i will get a foam roller soon.
    I was trying to quote you stretching quote, but BF was acting strange on my droid.

    Yoga is basically intense stretching. Hot yoga is even better for your joints.
    Might as well heal your body & mind in one shot.
    Its better than any shot a doc might give you...


    I tried a few Yoga stances after my trainer session, & this is the 1st time I woke up with muscle pains in a long time.
    Feels like I was weight training the day but before.
    Last edited by Ghost Ryder; 12-31-13 at 03:03 PM.
    Giant Defy Dura Ace : Rip/Hammer-Specialized Allez Ultegra/105 : Recovery/Spinner-Specialized Allez Red : Trainer-Kona Major(Rad) Jake : Down & Dirty

  22. #72
    Long Distance Cyclist Machka's Avatar
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    Quote Originally Posted by hillcrawler View Post
    When you say Yoga that is the first thing comes to my mind.
    As Ghost Ryder says, yoga is stretching ... and if you're in a good class, it is stretching with guidance to teach you how to stretch properly without injuring yourself.

    I haven't taken a pilates class yet, but I've heard it is even more intense than yoga, and good for core building as well.

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