I used an A2Z adapter on a half-bike: a dual suspension Jamis Dakar Team. It worked ok, with the following issues:
1. The left dropout must have a pretty good sized, flat profile to clamp the adapter onto--you need a lot of surface area. Most alu frames fit this criteria, but some don't. The adapter attaches with a series of bolts that squeeze it against a relatively wide, flat dropout. It also uses the squeezing force of the rear quick release
2. You have to remove the rear quick release entirely to remove the rear wheel. On my Jamis, I always had difficulty getting the wheel in and out of the dropout / A2z adapter combination. That may have had something to do with the shape of the locknuts on the hub I was using, or it may have been the adapter. I couldn't tell. The hub was a Magura Louise pro.
3. I got a random rubbing, ringing sound of the disc rubbing on something as I rode. I could not tell if that was an issue with the wheel, any play in the frame, or the adapter. It was random in the sense that it started, then stopped randomly, under various conditions, and there was never any particular pattern to this annoying behavior.