That's the question that I would like some advice in hopes of an answer. For the most part, a long ride for me due to time constraints is a 25 mile round trip either on one of my solo bikes, or with one of the kids or my wife on one of our tandems. No problems in seat discomfort on such a distance - that is unless I do it three or four days in a row. Which leads me back to last summer's experience on RAGBRAI where we spent quite a few hours in the saddle every day (not that the mileage was that much as I think it averaged around 70 a day, but the hours in the saddle with a child stoker on 26" wheeled tandems add up).
I didn't get saddle sores, but I did get saddle sore - as in deep muscles that did not take kindly to day 5, 6 and 7 of a 7 day ride. My seat on the tandem seems to be adjusted and dialed in to where I like it and I have not been using anything designed in particular for long distance riding in the way of a saddle (a Bontrager FS2000):
I guess this saddle is more geared for mountain biking and may not be the type of long distance saddle I need for proper sit bone/muscle support on a tandem. I just happen to use it on my mountain bikes and since it was broken in decided to use it on the tandem as well. I would dread sitting on the seat in the morning after the first few days of RAGBRAI last year. All I can do to describe it is a deep muscle pain that would not go away.
For those of you that have been through the trial and error process of finding a good supportive saddle that limits the soreness from saddles over longer distances on a tandem tour - what have you found or learned that helped address the soreness, or at least help limit it?