Nick Smolinske sewed me up a custom framebag for my Surly Karate Monkey for some off-road touring, and the process was really easy and his prices are super reasonable. If you've been kinda-sorta-thinking about getting a custom framebag, this might be exactly what you're looking for:
Here's my full review with a bunch of pictures.
Here's the bag I had made:
Hot damn, that's a gaudy bike!
My framebag is a dual-compartment bag. The drive side has a map pocket, and the non-drive side has the main access pockets. The internal divider folds up if I have to carry something bigger. All the contact points are padded and reinforced, as are the straps. Bombproof!