I've biked across Nevada a half dozen times and would highly recommend it for those who are looking for empty roads and wide open vistas. It is, however, extremely remote. Nevada touring is not for the beginner.
I'm curious about other folks who have ridden across the state. The Western Express Route sends you along US 50. I've done that road twice and I know the state has nicknamed it "The Loneliest Road" - but based on my experience (and traffic volume data) US 6 has less than half the traffic of US 50 - many stretches with 200 cars per day. What's more, US 6 is a great route that connects up with Calif 120 and takes you into Yosemite National Park over Tioga Pass. Either route is tough going west with prevailing west winds - although I've had my share of east winds when I was heading east - this year in particular.
What's of greatest concern for the cyclist is water. Between Tonopah and Ely on US 6 - it's 168 miles. The only public establishment is a little gas station/store at Lockes halfway between the two. It's actually someone's house with a room added to do business as needed. The rest area at Saulsbury Wash doesn't have water, but you can usually wait for an RV to come along and beg some. There's a ranch near the road in the Stone Cabin Valley. The bar at Warm Springs is long abandoned. The pool is still there with a fence and a big "No Trespassing" sign - but there's an even bigger hole in the fence. Even filtered, I wouldn't drink this water - sulphury - yeech! Next, there's a road crew station at Blue Jay and a ranch house nearby where you can ask for water. After Lockes, the bar/restaurant at Currant is shut down. There are a couple of trailers out back where ranch crews live. If someone is home, they'll give you water. Finally, there's the little community of Lund a few miles off the highway just before you climb up to Ely.
Oh yes - the casino on the California border is now closed as is the Mizpah Hotel. And Coaldale Jct is abandoned, as well. Did I say empty?? I really do prefer US 6. It's some of the best touring in the United States. If you've done it - what do you think?
Best - J
P.S. If you take US 6 please be careful when you are near Area 51 or you just might get abducted by aliens.