Saddle sores seem better prevented than treated. Once they form, they are a pain, and a pain to deal with. And they can seriously disrupt a trip. If they can be prevented from forming in the first place, it seems like a much better way to go.
One approach is to prevent tissues from becoming more susceptible to infection.
If pressure is kept on those tissues (the tissues that are smashed between the bones and the saddle), blood cannot circulate normally. If the oxygen supply to those tissues is inadequate, the tissues are weakened, and are less able to fend off infections. They can then become much more likely to admit the formation of saddle sores (which are one form of infection).
"Tissue ischemia" is the medical term; but it just means restricted blood (and so restricted oxygen supply) to the tissue:
In medicine, ischemia (Greek ισχαιμία, isch- is restriction, hema or haema is blood) is a restriction in blood supply, generally due to factors in the blood vessels, with resultant damage or dysfunction of tissue.
No blood, no oxygen, no healthy tissues....
A recipe for infection, through inadequate oxygen supply.
Moving around on the saddle, standing once in a while to restore blood flow and oxygen supply to those tissues, stopping and walking around a bit, perhaps a brief massage of the area once in a while: all these things can prevent the restriction of blood supply from becoming problematic.
One source indicated that 3-4 minutes at a stretch was as long as the blood supply should be cut off. (This makes sense -- living tissues and their cells need frequent supplies of fresh blood and oxygen...) So standing or shifting around, or somehow promoting or restoring blood flow every few minutes makes a lot of sense.
There are probably additional approaches that help prevent saddle sores, too. Preventive antibiotic ointments are sometimes used.
It seems best to keep the tissues healthy, though, and then to use other approaches as supplementary, on that foundation of healthy tissue.
Good hygiene certainly seems important.
Any other good approaches to preventing saddle sores out there?
What are the best antibiotic ointments, and are they worth using even if the tissues are not allowed to become ischemic, and are kept in good health?