Join Date: Apr 2008
Location: Melbourne, Australia
Bikes: Specialized Tricross Sport 2009
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Use Sheldon Brown's gear calculator. Depends a lot on how much weight you're carrying, how strong you are, and how fast you're planning to power up these hills. To me, 42x30 sounds far too high for carrying *any* load up *any* hill, but maybe you're in great condition. My lowest gear is 30x34 (yes, bigger at the rear than the front), and I'm considering going even lower for hilly touring. If you haven't toured before, you're in for a surprise - the extra weight makes even mild hills a lot harder.
42x14 highest gear would be about middle range for me. IMHO that would be tedious for 110 miles.