Obviously much must depend on your hands and personal preferences. I've had some old non hooded levers, old Shimano 600 aero levers, Cane Creek SCR-5s(?) and the newer Shimano STI levers.
Hands down for me, the newer Shimano STI levers win. They just feel so much more comfortable to me. I do like the Cane Creeks, but have this nagging feeling that because of the angle I like to have them and have the Shimano STIs, in an emergency braking situation from the hoods, my hands could slip right over them. That (and it might just be a perception, not a reality) just puts me off a little. Plus I feel the Cane Creeks are for bigger hands, and the Shimano for smaller hands, and I'm on the smaller hand side. But YMMV.