Join Date: Dec 2010
Location: northern Deep South
Bikes: Fuji Touring, Novara Randonee
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Rear shouldn't be a problem, as all (recent) Shimano derailers have the same pull.
Front could be iffy with a brifter. I'm running fine with a Tiagra FD on some kind of Shimano crank (46-36-26), but some people claim they don't match. You can go to either a Campy front brifter (ratcheting, not indexed), bar-ends, or a down-tube shifter if that floats your boat.
FYI, there's quite a few touring bikes spec'ed with a mountain crank, so what you're suggesting is not uncommon.