Join Date: Jan 2005
Location: Brussels, Belgium
Bikes: Trek 5500 + 6500
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last summer I've ridden the Rhone vally from St Etienne to the Mediterranean coast. I think the most important advantage, is the possibility to have the Mistral winds in your back (when you travel from north to south). When I was there, winds were blowing at around 80km/h, which made it very easy to me to ride (full packed) at around 35km/h on average! So if you consider doing it, keep an eye on the wether forecast.
On the other hand, the road along the Rhone vally is a so called "route nationale" which means it has quite heavy traffic.
I would suggest to take it of you want to travel on a fast way through the region. If you have more time, take the smaller and more quiet roads of the Massif Centrale which have very scenic views.