I'm currently doing a tour of the west coast (Portland - San Diego), and am currently 1,200mi into it. I've had knee issues (iliotobial band friction syndrome) that I am now thankfully over, after having bought a foam roller.
One remaining niggle, though, is my grip strength.
After about three days on tour, I noticed I had little tremors and twitches in my fingers. That was due to me putting pressure on the central base of the hand when riding, so I stopped that and the tremors and twitches went away quickly.
However, I've got some pretty massive grip fatigue. It's not affecting my riding in any way, but my thumb/index finger pinching grip is very weak. I can't eat with chopsticks, hold a wine glass by the stem in the normal way or any action that requires pinching (writing is ok, however).
There's no pain, tingling, numbness or anything of that sort going on.
I ride with padded gloves most of the time, but take them off just for variation at other times.
I had my bike professionally fitted, and while they wanted to lower the stem a little bit (the saddle is more or less level with the top handlebars), everything else should be ok.
This is my bike: