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Old 03-17-10, 09:35 AM   #1
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New medical study

Much of America's health problems are a result of chronic inflammation.
We're talking dozens of diseases.

A new drug shows some promise in controlling inflammation.

"The drug, salsalate, which is related to aspirin but is not as hard on the stomach, has been used for years to treat arthritis and joint pain. Patients who took it as part of a randomized clinical trial led by researchers at the Joslin Diabetes Center improved their blood sugar levels after three months, with those taking the highest dose lowering their hemoglobin A1C scores by 0.5 percent on average. Patients who took the drug also lowered their triglycerides.

“The potential is really exciting,” said Dr. Allison B. Goldfine, Joslin’s director of clinical research and the lead author of the paper, which will be published in Tuesday’s Annals of Internal Medicine. “We may have a new class of therapeutic agents to treat patients with Type 2 diabetes, and when you have a new safe, effective and inexpensive agent, that’s pretty exciting.”

Even more importantly, the work may help unravel the root causes of diabetes, said Dr. Steven E. Shoelson, the paper’s senior author and head of Joslin’s research section on pathophysiology and molecular pharmacology, and professor of medicine at Harvard Medical School.

“If we can figure out how this is working, we can figure out some of the root causes of diabetes and how obesity promotes inflammation, and how inflammation promotes diabetes and other chronic health problems,” Dr. Shoelson said."

You may have seen me talk about inflammation before, here is confirmation.

There is a wide variety of things that control or prevent inflammation.
Just something to be aware of...

http://www.nytimes.com/2010/03/16/he...tml?ref=health
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Old 03-17-10, 02:34 PM   #2
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A new drug shows some promise in controlling inflammation.
But we all know what the greatest drug is. Its been around since time began.

Better diet. Increased exercise. Better lifestyle.

Consume $hit, feel like $hit.

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We can figure out some of the root causes of how obesity promotes inflammation
Is that real???... Did I just read that.


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Patients who took the drug also lowered their triglycerides.
Green tea does that.

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Old 03-17-10, 02:57 PM   #3
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Yes.... Yes Yes...

I can go out & eat junk food... I can go out a eat tons of ice cream...

Salsalate is here... My saviour.

If available, I wonder what the prescription rate for Salsalate in Okinawa would have been.
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Old 03-17-10, 05:08 PM   #4
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A new drug shows some promise in controlling inflammation.
Let me quote wikipedia

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Inflammation is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue. Inflammation is not a synonym for infection. Even in cases where inflammation is caused by infection, the two are not synonymous: infection is caused by an exogenous pathogen, while inflammation is one of the responses of the organism to the pathogen.

In the absence of inflammation, wounds and infections would never heal and progressive destruction of the tissue would compromise the survival of the organism.
We should not be attempting to "control inflammation" without first attempting to remove the item(s) that are causing the inflammation.
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Old 03-17-10, 05:59 PM   #5
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Where trying to figure out some of the root causes of how obesity promotes inflammation & how we can develop drugs to control it.

Next sentence.

We don't want to see our good citizens of the US stop gorging our faces in Big Macs & Ice cream. We don't want that, what we want is to spend billions $'s in tax payers money developing drugs to treat the mentally weak ba$tards who can't stop eating.

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Old 03-17-10, 06:12 PM   #6
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Theres your salsalate pills, enjoy your $40 Mcdonalds meal. yeeeeeeeeeeaaaaaahhhhhhhhhh. Inflammation controlled.

Hey Doc, Any medication for me to take, to stop me from turning red trying to get to the porch or when trying to tie my shoelaces???

Where very keen on developing something like that in the near future actually. For now & all time, we want all our citizens to remain fat ba$tards. Drugs will sort it.

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Old 03-17-10, 06:33 PM   #7
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We should not be attempting to "control inflammation" without first attempting to remove the items that are causing the inflammation.
Ever slam a hammer on your thumb? The body overreacts.

You can eat a diet that will control inflammation quite well. It is so austere that
basically nobody does it.

Certainly diet and exercise play a role.

But a lot of people will get help from something like this.
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Old 03-17-10, 07:06 PM   #8
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We should not be attempting to "control inflammation" without first attempting to remove the item(s) that are causing the inflammation.
You're right, in that acute inflammation can be useful. It is a protective and healing mechanism.

Chronic, low-level inflammation is not, though. The article also says that the most exciting thing is that it may help us understand the precise mechanism of inflammation better, not that the drug itself proved useful (though that is good in itself). Don't forget that until relatively recently, the immune and inflammatory aspects of atherosclerosis were not widely recognized. It was largely considered a passive process, which hurt our efforts to treat it. Even our understanding of cholesterol and other (possibly better) predictors of heart disease, something we have held as truth for some time, is evolving at this moment. Some of these discoveries were made by observations of the effects of some drugs, such as aspirin.

If you live long enough, no matter what you eat or do, some aging process will catch you, and many of these are inflammation-mediated. Some people are also naturally prone to these things. People of "healthy" build have heart attacks, too. So do people with "normal" cholesterol levels. People who ride their bikes a lot also have heart attacks. Getting old sure does suck. It's all downhill from about 20.

Why not have the drugs handy when other measures fail?

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We can figure out some of the root causes of how obesity promotes inflammation
Quote:
Is that real???... Did I just read that.
I don't see why you're so surprised, unless you claim to know something no one else does. Why is being fat bad for us, exactly? How does it cause inflammation? "Well, clearly it's unnatural and fat people eat McDonald's, so fat causes inflammation" isn't good enough. What is the specific physiology there? The answer is that we don't really know. It may be possible that obesity and other poor health habits are simply correlative, and that obesity isn't actually what we should be worried about.

Saying that everything can be fixed by eating a proper (read: upper-class, educated, white people food) diet, or the Paleo diet, or the Mediterranean diet, or whatever fad is hot this month is dilettantism at best.
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Old 03-17-10, 07:08 PM   #9
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Ever slam a hammer on your thumb? The body overreacts.
No, not really, the body does what it needs to do to repair itself. If you end up with a sore thumb for a day pop a pain pill, don't short circuit the body's repair functions.

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You can eat a diet that will control inflammation quite well. It is so austere that
basically nobody does it.
Yep, eat a celiac diet like the racing teams do. OTOH popping a pill to deal with the chronic inflammation from an intentionally improper diet seem like a horrible, bad, no good, idea.

http://www.mensjournal.com/winning-without-wheat

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But a lot of people will get help from something like this.
No, most people will use it as a crutch to continue to do what they want when their body is telling you that you should not. The only people that should be taking something like this are people suffering from chronic inflammation like RA.
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Old 03-17-10, 07:20 PM   #10
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So we're basically arguing that although drugs such as these can be useful, the way in which they're likely to be used is questionable.

Remember when, not so long ago, there was talk of proactively putting most people on statins?
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Old 03-17-10, 07:36 PM   #11
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So we're basically arguing that although drugs such as these can be useful, the way in which they're likely to be used is questionable.

Remember when, not so long ago, there was talk of proactively putting most people on statins?
Correct. Treating chronic inflammation because of RA or other disorders that can not be corrected through lifestyle is a good thing; using it to treat chronic bad habits or acute attacks from intentional abuse of the body seems like it will be the most common and improper use.
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Old 03-17-10, 07:53 PM   #12
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The answer is that we don't really know.
The answer is, what we consume directly affects our health. Our bodies are going to rebel if mistreated. Put toxic fumes into the earths atmosphere, mistreat the planet, its going to rebel back at us, melting ice caps, rising seas. Why do the longest living people on earth on Okinawa island live the longest & have no major cases of inflammation?.




Caloric Restriction, Metabolic Damage and Aging

One of the most durable theories of aging is the free radical theory. This theory postulates that damage from free radicals (unstable molecules), generated mainly from metabolizing food into energy, ultimately damages vital body molecules (tissue, DNA, etc.). This damage accumulates with time until, like an old car, we fall apart. In support of this theory, one of the most important findings in free-radical research has been that eating fewer calories increases life span (Sohal RS, et al. Science 1996;273:59-63; Heilbronn LK, et al. Am J Clin Nutr 2003;78:361-9). The initial evidence that this may work in humans has been indirect and based on observation of the low caloric intake of the Okinawans and their long life expectancy (Willcox DC, et al. Biogerontology 2006). More direct evidence suggests that Okinawans following the traditional ways have low blood levels of free radicals. The elders had significantly lower levels of lipid peroxide-compelling evidence that they suffer less free-radical-induced damage. This may indicate healthier lifestyles but may also be due to gene variants that result in lower blood levels of free radicals.

Cancer and Aging

Okinawans are at extremely low risk for hormone-dependent cancers including cancers of the breast, prostate, ovaries, and colon. Compared to North Americans, they have 80% less breast cancer and prostate cancer, and less than half the ovarian and colon cancers. Some of the most important factors that may protect against those cancers include low caloric intake, high vegetables/fruits consumption, higher intake of good fats (omega-3, mono-unsaturated fat), high fiber diet, high flavonoid intake, low body fat level, and high level of physical activity.

The Role of Physical Activity in Healthy Aging

Okinawan centenarians have been lean throughout their extraordinarily long lives, with an average body mass index (BMI) that ranged from 18 to 22 (lean is less than 23). The Okinawans have traditionally kept eating a low-calorie, low glycemic load diet, practicing calorie control in a cultural habit known as hara hachi bu (only eating until they are 80% full), and keeping physically active the natural way. Particular exercise interventions are under study for their role in healthy aging.

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Old 03-17-10, 09:32 PM   #13
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I am buying stock in pharmaceutical companies.
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Old 03-17-10, 09:45 PM   #14
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Here are some other "drugs" that fight inflammation:

Almonds, oily fish (mackerel, wild salmon, sardines), sweet potatoes, chili peppers, cantaloupe, greens (collard, chard, kale) and if you don't like any of these there are plenty more.

Oh yeah, these all taste good and since you have to eat something they don't really cost anything.
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Old 03-17-10, 10:46 PM   #15
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Smiling, Laughing, and Loving are the biggest reducers of inflammation, imo.
I don't care what you eat, not being happy is the most inflammatory thing of all.
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Old 03-18-10, 06:55 AM   #16
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I'm sorry for the cynicism, but after being written a script for anti-depressants as a "pick-me-up" when I wasn't depressed, I just have an easy time seeing the abuse of medication like this.

I never did fill that prescription.
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Old 03-18-10, 06:57 AM   #17
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]The answer is, what we consume directly affects our health. Our bodies are going to rebel if mistreated. Put toxic fumes into the earths atmosphere, mistreat the planet, its going to rebel back at us, melting ice caps, rising seas.
Anthropomorphizing nature is unscientific, and an appeal to emotion.

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Why do the longest living people on earth on Okinawa island live the longest & have no major cases of inflammation?.
Does exercise lead you to be more energetic, or does being naturally energetic lead you to exercise?

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Caloric Restriction, Metabolic Damage and Aging

One of the most durable theories of aging is the free radical theory. This theory postulates that damage from free radicals (unstable molecules), generated mainly from metabolizing food into energy, ultimately damages vital body molecules (tissue, DNA, etc.). This damage accumulates with time until, like an old car, we fall apart. In support of this theory, one of the most important findings in free-radical research has been that eating fewer calories increases life span (Sohal RS, et al. Science 1996;273:59-63; Heilbronn LK, et al. Am J Clin Nutr 2003;78:361-9). The initial evidence that this may work in humans has been indirect and based on observation of the low caloric intake of the Okinawans and their long life expectancy (Willcox DC, et al. Biogerontology 2006). More direct evidence suggests that Okinawans following the traditional ways have low blood levels of free radicals. The elders had significantly lower levels of lipid peroxide-compelling evidence that they suffer less free-radical-induced damage. This may indicate healthier lifestyles but may also be due to gene variants that result in lower blood levels of free radicals.
So what you're saying is that caloric restriction is unproven, and the health of Okinawans may be due to things they do or don't do, or it could also be just because they're genetically Okinawan.
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Old 03-18-10, 07:57 AM   #18
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Wow. Some harsh words without any knowledge behind them. There are millions of people who could benefit from a drug to reduce or eliminate a hyper-inflammatory response, and they're not people who are careless in their eating habits. And a change of diet doesn't help these people either.

People with asthma - a disease of inflammation of lungs and airways...

People with osteoarthritis or rheumatoid arthritis - both involving inflammation

People with Crohn's disease and inflammatory bowel disease - disease of inflammation.

People with chronic obstructive pulmonary disease.

Women with pelvic inflammatory disease.

People with chronic inflammatory skin disorders, like psoriasis, severe acne, eczema, lupus.
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Old 03-18-10, 09:39 AM   #19
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Wow. Some harsh words without any knowledge behind them. There are millions of people who could benefit from a drug to reduce or eliminate a hyper-inflammatory response, and they're not people who are careless in their eating habits. And a change of diet doesn't help these people either.

People with asthma - a disease of inflammation of lungs and airways...

People with osteoarthritis or rheumatoid arthritis - both involving inflammation

People with Crohn's disease and inflammatory bowel disease - disease of inflammation.

People with chronic obstructive pulmonary disease.

Women with pelvic inflammatory disease.

People with chronic inflammatory skin disorders, like psoriasis, severe acne, eczema, lupus.
and a guy that doesn't even know how to treat a pounded thumb...

oh well.
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Old 03-18-10, 07:56 PM   #20
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People with asthma - a disease of inflammation of lungs and airways...

People with osteoarthritis or rheumatoid arthritis - both involving inflammation

People with Crohn's disease and inflammatory bowel disease - disease of inflammation.

People with chronic obstructive pulmonary disease.

Women with pelvic inflammatory disease.

People with chronic inflammatory skin disorders, like psoriasis, severe acne, eczema, lupus.

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And a change of diet doesn't help these people either.
I hold firm, what we consume directly affects our health. All them conditions listed above can be offset via just one food, one glass of a drink, one supplement, one energy drink, one "heathy tea" etc etc. Millions of variables. Its about trial & error & taking mental & physical notes.

Maybe in a thousand years time, we will have finally of worked it out but that won't come via drugs. Look to the longest living people on earth & try to build on it.

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Old 03-18-10, 08:43 PM   #21
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I have suffered from Osteoarthritis since I was 14, I'm 24 years old now.

If they could give me a pill to resolve it, and it was remotely safe, I'd be all over it. It has impacted my entire life for the last decade in so many ways. Thankfully, I've found cycling and am back in control of my weight. I've always been a strong young man, but I've also varied between being lean and chunky since it's been pretty difficult to do cardio, I enjoy running. Should say enjoyed, =P.

I realize its not the same, but just another point of view for this. Unless of course, I can change my diet to eliminate the Osteoarthritis?
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Old 03-18-10, 10:39 PM   #22
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People I know with osteoarthritis have told me that eliminating grains, coffee, tea, all caffeine in general and eating more or less a paleo diet had helped immensely with their inflammation.
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Old 03-18-10, 10:54 PM   #23
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I have suffered from Osteoarthritis since I was 14, I'm 24 years old now.

If they could give me a pill to resolve it, and it was remotely safe, I'd be all over it. It has impacted my entire life for the last decade in so many ways. Thankfully, I've found cycling and am back in control of my weight. I've always been a strong young man, but I've also varied between being lean and chunky since it's been pretty difficult to do cardio, I enjoy running. Should say enjoyed, =P.

I realize its not the same, but just another point of view for this. Unless of course, I can change my diet to eliminate the Osteoarthritis?
So exercise has helped?

As the body struggles to contain ongoing damage, immune and regrowth processes can accelerate damage.

Why can't the body contain ongoing damage???. Personally, I believe your just "feeding" the condition which the your weakened immune system (genetic) can't fend off.

14 - 24 years. There must be something in your diet, gluten, milk, sugar etc something that you have consumed your whole life which must be feeding it.

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Old 03-19-10, 03:22 PM   #24
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So exercise has helped?

As the body struggles to contain ongoing damage, immune and regrowth processes can accelerate damage.

Why can't the body contain ongoing damage???. Personally, I believe your just "feeding" the condition which the your weakened immune system (genetic) can't fend off.

14 - 24 years. There must be something in your diet, gluten, milk, sugar etc something that you have consumed your whole life which must be feeding it.
If exercise helped, it's quite likely that the weight loss itself eased the arthritis, especially if in the knee.

So... the next person stricken with MS should just eat a granola bar or have a mango smoothie and it will make it all better??
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Old 03-19-10, 04:46 PM   #25
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What a load of crap...so people with genetic diseases should just wave a magic wand, change their diet, and it will be all better?

There are diseases where inflammation can be managed by diet, but slapping a blanket statement on anything and everything that might possibly involve inflammation is just being willfully ignorant.
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