I've been riding a Specialized Toupe for several years. I can use it for all kinds of rides but if the ride is long enough I will get some soreness. I have come to accept that. But this week I remounted a Fizik Alliante saddle to my Ti bike in anticipation of longer slower rides through the winter. The shape and padding of the Alliante dictates I raise my bars or the soft nose will cause numbness. I did that and rode nearly 50 miles yesterday in total comfort. No numbness or soreness. A century will be the next test. I have another Alliante that I will put on my Roubaix. I'll also have to raise the bars on that bike but I think the higher bar doesn't really affect my speed much at all. I'm so comfortable that I can just pedal well and as well late into the ride.
Fit is a dynamic thing for me but for longer rides comfort trumps all other considerations.