Highway 6 on the Bruce Peninsula is quite busy. I took quiet roads that ran to the east of 6. Dyers Bay Road to East Road. East Road becomes Forty Hills Road, which is unpaved, but hard packed, so easy to ride. Take CR 29 into Lion's Head, and CR 9 out of it. That will take you to Wiarton. East out of Wiarton, CR 1 is a beautiful road. Highway 26 is very busy, but there's a rail trail that parallels it from Meaford to Collingwood.
I've taken my bike on the Glenora Ferry many times. There's no problems, and it's free. In Prince Edward County, stop at Slickers in Bloomfield for the best ice cream in the world.
I would only make reservations at provincial parks if you're going to be there on the weekend. They charge a huge reservation fee, and I've never had a problem getting a site during the week.