Doctor Moribus and I don't disagree on this. I couldn't wait to get new wheels on mine, but I decided to buy a Roubaix Pro when I got a great deal on mine. My answer in this case was based on the useage of the bike - mostly commuting, and my theory there is, if it ain't broke don't fix it. If the original poster indicated that he was using the bike for group rides/racing or any number of sport useages, a wheel upgrade is the best thing one can do with a bike. Having said all that, I am about to do a 40 miler with my Sequoia with its Alex wheels this beautiful morning!
Remember my original answer comes from a guy who paid $2100 for a wheel set!