I'm almost starting to buy into Kurzweil's predictions of a technological 'singularity', which would make life past that point radically different and impossible to predict:
Kurzweil writes that, due to paradigm shifts, a trend of exponential growth extends Moore's law from integrated circuits to earlier transistors, vacuum tubes, relays, and electromechanical computers. He predicts that the exponential growth will continue, and that in a few decades the computing power of all computers will exceed that of human brains, with superhuman artificial intelligence appearing around the same time.
I truly love living through this period of great technologogical change, and a real downside of mortality is the things I will miss.