I ride with taped bullhorns and severely padded Trico gloves.
That said, I have found experimenting with stem angle and length has influenced my wrist comfort more than anything else.
I mean, the tape and the pads help, but the angle and position of the bars seems more important.
I now ride with an 80mm stem and a six degree rise, and I adust the angle of the bullhorns to match the natural angle of my wrists in that position.
With any other stem (and I have a collection) my wrists hurt.