Hi, I've owned my Trek 7300 since 2003, have over 6K miles on it and completely rebuilt it in 2010. I started riding it when I weighed 350 lbs and have been hovering around 290 for the last couple of years. My longest ride on it has been about 75 miles and it works great.
I live in Florida so I run a 12-23 in the back and use it for a commuter on occasion. I also change it to 9 speed versus the original 8 and got rid of the original suspension front fork as I could not lock it and decided to go with a steel fork. I also had my Velocity Deep V's restrung with XT hubs and run 25 versus the 38's that were the stock tire size. While I have change road bikes a few times, I will not get rid of this bike. I think it is really my favorite of all my bikes.
My wife has a 2003 Navigator 3.0 and while she has ridden 25-30 miles on occasion, it's not a comfortable ride for her, she does much better when I borrow a friends road bike from his wife as we check out bikes for her. I think the Navigators are more for short distances not the long rides, but each persons perspective is different.