In 1997 I had the chance to bike skyline drive and the blueridge parkway.
it was most likely the best trip I have done on 2 wheels.
Well Italy has their L'eroica and france has their event, And If do say there could not be a better piece of road to tour on.
Now this is just an idea-
I think the best time is when the fall colors come around.
Anybody interested?