I bought a defy 3 a few years ago as my first road bike. At the time I was about your size. It is a comfortable bike that you can do a lot of miles on. I did numerous metrics on it and a few centuries. I didn't like the 2200 level components and upgraded them to ultegra. Nicer shifting, no thumb shifters. No issues at all with the bike or the wheels. They have been bullet proof.
Since that time I have built a new bike. I still own the defy and ride it with my GF and on slower rides. My only real complaint with it is that it simply doesn't climb that well. Bouncing between it and my newer bike, I feel like I'm dragging an anvil behind me with the Giant.
Flat roads, downhills, small hills--excellent bike. Long and/or steep uphills--not a fun bike to be on.
Most people seem to hate it, but I absolutely love the saddle that came on that bike. It's like sitting in a lazy boy.